Purpose of Review

Most treatment algorithms and guidelines for acute intravenous (IV) treatments of migraine for children and adolescents are derived from adult studies and often based on clinician’s personal experience regarding what is known to work. An overview of the current level of evidence of different acute IV treatments for migraine and status migrainosus in children and adolescents may help to improve provider’s approach and will emphasize the need for research in this field.

Recent Findings

Dihydroergotamine (DHE) is the most common therapy used in the inpatient setting especially those with intractable migraine lasting > 72 h (i.e., status migrainosus) not responding to usual oral or IV treatments. There may be some role of continuous infusion of valproic acid in the same group not responding to DHE or cannot tolerate DHE.

Summary

The purpose of this paper is to investigate clinical evidence of different modalities of IV treatments for children and adolescents with an intractable migraine attack and to discuss possible upcoming future treatments.

中文翻译：

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儿童和青少年的静脉偏头痛治疗。

审查目的

儿童和青少年偏头痛急性静脉（IV）治疗的大多数治疗算法和指南均来自成人研究，并且通常基于临床医生对已知有效方法的个人经验。对儿童和青少年偏头痛和状态性偏头痛的不同急性IV治疗的当前证据水平进行综述，可能有助于改善提供者的方法，并将强调在该领域进行研究的必要性。

最近的发现

二氢麦角胺（DHE）是住院环境中最常用的治疗方法，尤其是对于持续时间不超过72小时的顽固性偏头痛（即偏头痛状态）的患者，对常规的口服或静脉治疗无效。在同一组中连续注射丙戊酸可能对DHE无反应或不能耐受DHE。

概要

本文的目的是调查难治性偏头痛发作的儿童和青少年静脉输注治疗不同方式的临床证据，并讨论可能的未来治疗方法。