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Males are more sensitive to reward and less sensitive to loss than females among people with internet gaming disorder: fMRI evidence from a card-guessing task.
BMC Psychiatry ( IF 4.4 ) Pub Date : 2020-07-07 , DOI: 10.1186/s12888-020-02771-1
Jialin Zhang 1 , Yan Hu 2 , Ziliang Wang 3 , Min Wang 1 , Guang-Heng Dong 1, 4
Affiliation  

Many studies have found an interesting issue in the Internet gaming disorder (IGD): males are always observed to be the majority. However, there are little research to exploring the differences in the neural mechanisms between males and females in decision-making process among people with IGD. Therefore, explore the reward/loss processing between different gender with IGD could help in understanding the underlying neural mechanism of IGD. Data from functional magnetic resonance imaging (fMRI) were collected from 111 subjects (IGD: 29 males, 25 females; recreational internet game user (RGU): 36 males, 21 females) while they were performing a card-guessing task. We collected and compared their brain features when facing the win and loss conditions in different groups. For winning conditions, IGD group showed hypoactivity in the lingual gyrus than RGU group, male players showed hyperactivity in the left caudate nucleus, bilateral cingulate gyrus, right middle frontal gyrus (MFG), right precuneus and inferior parietal lobule relative to the females. And significant sex-by-group interactions results showed higher brain activities in the thalamus, parahippocampal gyrus and lower brain activities in Inferior frontal gyrus (IFG) were observed in males with IGD than females. For losing conditions, IGD group showed hypoactivity in the left lingual gyrus, parahippocampal gyrus and right anterior cingulate cortex (ACC) compared to the RGU group, male players showed hyperactive left caudate nucleus and hypoactive right middle occipital gyrus relative to females. And significant sex-by-group interactions results showed that compared to females with IGD, males with IGD showed decreased brain activities in the IFG and lingual gyrus. First, there appeared to be no difference in reward processing between the IGD and RGU group, but IGD showed less sensitivity to loss. Secondly, male players showed more sensitivity to rewards and less sensitivity to losses. Last but not least, males and females showed opposite activation patterns in IGD degree and rewards/losses processing. And male IGD subjects are more sensitive to reward and less sensitive to loss than females, which might be the reason for the gender different rates on IGD.

中文翻译:

在患有网络游戏障碍的人群中,男性比女性对奖励更敏感,对损失更不敏感:来自卡猜任务的fMRI证据。

许多研究发现互联网游戏障碍(IGD)中有一个有趣的问题:男性总是占多数。然而,很少有研究探讨IGD患者在决策过程中男性和女性神经机制的差异。因此,探索IGD在不同性别之间的报酬/损失过程可能有助于理解IGD的潜在神经机制。来自功能磁共振成像(fMRI)的数据是在执行卡猜任务时从111位受试者(IGD:29位男性,25位女性;休闲互联网游戏用户(RGU):36位男性,21位女性)中收集的。我们收集并比较了他们在面对不同群体的得失情况时的大脑特征。对于获胜条件,相对于雌性,IGD组在舌状回中的活动性较RGU组低,男性演奏者在左尾状核,双侧扣带回,右中额回(MFG),右前突和顶下小叶活动性增强。显着的性别间交互作用结果显示,IGD男性比女性中丘脑,海马旁回和较高的额下回(IFG)脑活动更高。与RGU组相比,IGD组在失去条件方面表现出左舌回,海马旁回和右前扣带回皮层(ACC)的活动不足,男性球员相对于女性表现出左尾状核活跃,右枕中回活跃。显着的性别间相互作用结果表明,与具有IGD的女性相比,具有IGD的男性在IFG和舌状回中的大脑活动减少。首先,IGD和RGU组之间的奖励处理似乎没有差异,但是IGD对损失的敏感性较低。其次,男性玩家对奖励的敏感性更高,对损失的敏感性更低。最后但并非最不重要的一点是,男性和女性在IGD程度和奖赏/损失处理中表现出相反的激活模式。与男性相比,男性IGD受试者对报酬更敏感,对损失更不敏感,这可能是造成IGD性别差异的原因。但是IGD对损失的敏感性较低。其次,男性玩家对奖励的敏感性更高,对损失的敏感性更低。最后但并非最不重要的一点是,男性和女性在IGD程度和奖赏/损失处理中表现出相反的激活模式。与男性相比,男性IGD受试者对报酬更敏感,对损失更不敏感,这可能是造成IGD性别差异的原因。但是IGD对损失的敏感性较低。其次,男性玩家对奖励的敏感性更高,对损失的敏感性更低。最后但并非最不重要的一点是,男性和女性在IGD程度和奖赏/损失处理中表现出相反的激活模式。与男性相比,男性IGD受试者对奖赏更敏感,对损失更不敏感,这可能是造成IGD性别差异的原因。
更新日期:2020-07-07
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