In the current study, a green, one-pot, three-component reaction was performed to prepare novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction of a ketene S,S-acetal of Meldrum’s acid or barbituric acid (as key intermediates), hydrazine, and isothiocyanate. The key advantages of this manner include environmentally safe reactions, high yield, appropriate reaction time, simple reaction conditions, and use of a green reaction solvent. The structure of thiadiazoles was determined based on the spectroscopic data.

中文翻译：

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一锅绿色合成一些新型的N取代的5-氨基-1,3,4-噻二唑衍生物

在当前的研究中，进行了绿色的一锅三组分反应，以制备新型的N-取代的5-氨基-1,3,4-噻二唑衍生物。噻二唑是由Meldrum酸或巴比妥酸（作为关键中间体）的乙烯酮S，S-乙缩醛，肼和异硫氰酸酯反应制得的。这种方式的主要优点包括对环境安全的反应，高收率，适当的反应时间，简单的反应条件以及使用绿色反应溶剂。噻二唑的结构是根据光谱数据确定的。