The present work was aimed to synthesize eight new diphenylamine derivatives by the reactions of 2-chloro-N-(4-(diphenyl amino) thiazol-2-yl)acetamide with substituted phenols in the chloroform along with anhydrous potassium carbonate and potassium iodide. The structures of newly synthesized compounds were characterized by IR, NMR, Mass and elemental analysis techniques. Toxicity profile (acute and subacute oral toxicity) and biological activity (analgesic and anti-inflammatory activity) of the synthesized derivatives was performed. Findings of the present work suggested that the synthesized compounds may be one of the excellent potent compounds to treat pain and inflammation. Therefore compounds of this group especially AK-4 (N-(4-(diphenylamino)thiazol-2-yl)-2-(2- nitrophenoxy)acetamide) could be an excellent starting point to build up new lead compounds in the management of pain and inflammation.

本工作旨在通过2-氯-N-（4-（二苯基氨基）噻唑-2-基）乙酰胺与氯仿中的取代酚以及无水碳酸钾和碘化钾的反应合成八种新的二苯胺衍生物。通过IR，NMR，Mass和元素分析技术对新合成化合物的结构进行了表征。进行了合成衍生物的毒性特征（急性和亚急性口服毒性）和生物学活性（镇痛和抗炎活性）。本工作的发现表明合成的化合物可能是治疗疼痛和炎症的极好的有效化合物之一。