Aquaporin-4 (AQP4) neuromyelitis optica spectrum disorder (NMOSD) has been demonstrated to be associated with non-organ and organ-specific autoantibodies (antinuclear antibody, extractable nuclear antibody, double-stranded DNA, muscle acetylcholine receptor antibody) and systemic autoimmune diseases. In this study, we evaluated whether a similar association with non-organ and organ-specifc autoantibodies occurs in patients with MOG-IgG1-associated disorders. We determined that MOG-IgG1 was not strongly associated with these organ and non-organ-specific autoantibodies. Systemic lupus erythematous (SLE) was significantly associated with AQP4-IgG+ NMOSD and not with MOGAD (p = 0.037). These findings suggest differences in co-existing systemic and organ-specific autoimmunity between MOGAD and AQP4-IgG+ NMOSD.

中文翻译：

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MOG-IgG1 相关疾病与 AQP4-IgG+ NMOSD 共存的全身性和器官特异性自身免疫

Aquaporin-4 (AQP4) 视神经脊髓炎谱系障碍 (NMOSD) 已被证明与非器官和器官特异性自身抗体（抗核抗体、可提取核抗体、双链 DNA、肌肉乙酰胆碱受体抗体）和全身性自身免疫性疾病有关. 在本研究中，我们评估了 MOG-IgG1 相关疾病患者中是否存在与非器官和器官特异性自身抗体类似的关联。我们确定 MOG-IgG1 与这些器官和非器官特异性自身抗体没有强相关性。系统性红斑狼疮 (SLE) 与 AQP4-IgG+ NMOSD 显着相关，而与 MOGAD 无关（p = 0.037）。这些发现表明 MOGAD 和 AQP4-IgG+ NMOSD 之间共存的全身性和器官特异性自身免疫存在差异。