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Reaction Calorimetry in Continuous Flow Mode: A New Approach for the Thermal Characterization of High Energetic and Fast Reactions
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2020-07-07 , DOI: 10.1021/acs.oprd.0c00117
Frederik Mortzfeld 1 , Jutta Polenk 1 , Bertrand Guelat 1 , Francesco Venturoni 1 , Berthold Schenkel 1 , Paolo Filipponi 1
Affiliation  

A new method for the calorimetric characterization of high-energetic, fast reactions in flow mode was developed. The use of an engineered flow reactor in combination with a process modeling software allowed the deconvolution of the reaction enthalpy from space-resolved temperature profiles. The new procedure was verified in a comparison with a conventional batch calorimeter and subsequently implemented for the thermal characterization of an organolithium flow process. The information collected for this reaction successfully supported a scale-up to the pilot plant. Overall, the new approach resulted in being superior when compared with established procedures, enabling the generation of precise calorimetric data in an accurate scale-down flow device.

中文翻译:

连续流模式下的反应量热:高能快速反应热表征的新方法

开发了一种新的方法来表征流动模式下的高能快速反应。将工程流程反应器与过程建模软件结合使用,可以使反应焓从空间分辨的温度分布图中解卷积。与常规的量热仪进行了比较,对新程序进行了验证,随后将其用于有机锂流动过程的热表征。为该反应收集的信息成功支持了规模扩大到中试工厂。总的来说,与已建立的程序相比,新方法具有优越性,从而可以在精确的按比例缩小的流量设备中生成精确的量热数据。
更新日期:2020-07-07
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