Objective. In the present clinical trial, we evaluated the therapeutic effects of low-intensity extracorporeal shockwave therapy (LiESWT) on overactive bladder (OAB). Methods. Female subjects with ages of 20-75 years and who have been clinically diagnosed with OAB were included in the study. The LiESWT (DUOLITH SD1 T-TOP, AG) applicator was placed on the suprapubic skin area and applied with an intensity of 0.25 mJ/mm², 3000 pulses, and 3 pulses/second. To assess the therapeutic efficacy, all subjects were required to complete the validated OAB symptoms and life bothersome questionnaires, 3-day urinary diary, uroflowmetry, and post-voided residual urine (PVR) measurement at 4 weeks of LiESWT (W4), 8 weeks of LiESWT (W8), 1-month follow-up (F1), and 3-month follow-up (F3) after LiESWT. Result. 82 subjects with the mean age of were enrolled. The questionnaire scores were significantly improved at W4, W8, F1, and F3 as compared to baseline data (W0). At W8, the mean values of functional bladder capacity were meaningfully increased. According to the 3-day urinary diary, daytime frequency, urgency, and nocturia were significantly decreased. The uroflowmetry results showed that the mean voided urine volume and the maximal flow rate () were noticeably increased. PVR volume was also significantly decreased. Conclusions. The data demonstrated that 8-week LiESWT ameliorated the OAB symptoms, promoted the uroflow parameters, and improved the quality of life (QoL) in OAB patients, suggesting that LiESWT might serve as an alternative noninvasive therapy for OAB.

中文翻译：

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低强度体外冲击波治疗可改善膀胱过度活动症：一项前瞻性试点研究。

客观。在目前的临床试验中，我们评估了低强度体外冲击波疗法 (LiESWT) 对膀胱过度活动症 (OAB) 的治疗效果。方法。该研究包括年龄为 20-75 岁且临床诊断为 OAB 的女性受试者。将 LiESWT (DUOLITH SD1 T-TOP, AG) 涂抹器放置在耻骨上皮肤区域并以 0.25 mJ/mm ^{2的强度涂抹}、3000 个脉冲和 3 个脉冲/秒。为了评估治疗效果，所有受试者都必须在 LiESWT 的第 4 周（W4）、第 8 周完成经过验证的 OAB 症状和生活困扰问卷、3 天尿日记、尿流测量和排尿后残余尿（PVR）测量LiESWT (W8)、1 个月随访 (F1) 和 LiESWT 后 3 个月随访 (F3)。结果。82 名受试者，平均年龄为被录取了。与基线数据 (W0) 相比，问卷分数在 W4、W8、F1 和 F3 显着提高。在第 8 周，功能性膀胱容量的平均值显着增加。根据3天的排尿日记，日间尿频、尿急、夜尿明显减少。尿流测定结果显示平均排尿量和最大流量（）显着增加。PVR 量也显着减少。结论。数据表明，为期 8 周的 LiESWT 改善了 OAB 症状，促进了尿流参数，并改善了 OAB 患者的生活质量 (QoL)，这表明 LiESWT 可能作为 OAB 的替代无创疗法。