Gut health is critically important for growing neonatal calves and nutritional technologies are needed to prevent disease and stress challenges. Previous work feeding Monensin (MON) in combination with an oregano, prebiotic, and Co-lactate (EOC) blend had demonstrated improved calf gut health and growth performance. The objective was to evaluate MON and EOC alone or in combination on calf growth performance. Eighty (80) new born Holstein (37) female and (43) male calves were randomly assigned to one of four treatments arranged in a 2 x 2 factorial (MON and EOC). Treatments were: 1) Control without MON or EOC added to the calf starter (CS); 2) MON: 50.8 mg/kg CS (Elanco, Greenfield, IN); 3) EOC: 44.1 mg/kg CS (Rum-A-Fresh, Ralco Inc. Marshall, MN); 4 ) MON+EOC: MON and EOC added to CS. Calves were fed colostrum followed by whole milk through weaning at 42 d, while CS was fed ad libitum through the 70 d experimental period. The MON by EOC interaction was found to be nonsignificant (P > 0.41) for growth performance. Calves fed without or with MON demonstrated similar (P > 0.70) body weight (BW; 68.7 and 68.9 kg without and with MON, respectively), while calves fed EOC demonstrated greater (P < 0.01) BW (67.3 and 70.4 kg without and with EOC, respectively) compared with calves fed without EOC. Calves fed a CS containing MON were similar (P > 0.47) in ADG (0.88 and 0.91 kg/d) compared with calves fed without MON, however feeding calves a CS with EOC increased (P < 0.01) ADG (0.84 and 0.95 kg/d) 13% through the 70 d experimental period compared with calves not fed EOC. Frame measurements indicated that the greater ADG was due to increased (P < 0.10) frame growth for calves fed EO compared with calves fed without EO. A Monensin by EOC interaction (P < 0.01) for serum propionate concentration demonstrated calves fed MON+EOC and EOC were greater (P < 0.05) compared with calves fed Control, while calves fed MON were intermediate and different (P < 0.05 ). Feeding calves, a CS with EOC increased (P < 0.04) IgA, IgG, and IgM concentrations compared with calves fed without EOC. A MON by EOC interaction was detected (P < 0.01) for total tract starch digestibility for calves fed EOC or MON+EOC demonstrating greater (P < 0.05) starch digestibilities than Control fed calves. These data demonstrate that EOC and MON fed in combination was not beneficial for enhancing growth performance, but that calf growth performance can be improved with EOC compared to MON.

中文翻译：

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将单独含有莫能菌素的牛犊起子或与牛至和钴的混合物喂入荷斯坦牛犊。

肠道健康对于新生牛犊的生长至关重要，需要营养技术来预防疾病和压力挑战。以前的工作将莫能菌素（MON）与牛至，益生元和乳酸（EOC）混合物混合使用，已证明改善了小腿肠的健康和生长性能。目的是评估MON和EOC单独或结合使用对小牛生长性能的影响。将八十只（80）新生荷斯坦（37）雌性和（43）雄性犊牛随机分配到按2 x 2阶乘（MON和EOC）安排的四种处理之一。处理方法是：1）对照，不向小腿起跑器添加MON或EOC（CS）; 2）MON：50.8 mg / kg CS（伊兰科，格林菲尔德，印第安纳州）；3）EOC：44.1 mg / kg CS（Rum-A-Fresh，拉尔科公司，明尼苏达州）；4）MON + EOC：MON和EOC已添加到CS。在第42天给小牛喂牛初乳，然后通过断奶喂全脂牛奶，在整个实验的70天给CS喂牛。发现EOC相互作用的MON对生长性能无显着影响（P > 0.41）。饲喂或不饲喂MON的犊牛的体重相似（P > 0.70）（BW;饲喂和不饲喂MON的犊牛分别为68.7和68.9 kg），而饲喂EOC的犊牛的体重却更高（P <0.01）（饲喂和不饲喂MON的体重为67.3和70.4 kg EOC）与没有EOC喂养的犊牛相比。饲喂CS中含有MON的犊牛相似（P与没有MON饲喂的犊牛相比，ADG（> 0.87和0.91 kg / d）的> 0.47），但是在70 d实验期间，饲喂带有EOC的犊牛的CS含量增加了（P <0.01）ADG（0.84和0.95 kg / d）13％。与未喂食平机会的犊牛相比。框架测量结果表明，饲喂EO的犊牛与未饲喂EO的犊牛相比，ADG值更高是由于生长增加（P <0.10）。莫能菌素通过EOC交互作用（P <0.01）对血清丙酸盐浓度的影响表明，与对照组相比，MON + EOC和EOC饲喂的犊牛更大（P <0.05），而MON饲喂的犊牛介于中间和不同（P <0.05）。饲喂犊牛，CS的EOC增加（P<0.04）与没有EOC喂养的犊牛相比，IgA，IgG和IgM的浓度。通过饲喂EOC或MON + EOC的牛的总淀粉消化率检测到通过EOC相互作用的MON（P <0.01），表明淀粉的消化率比对照饲喂的牛更高（P <0.05）。这些数据表明，联合使用EOC和MON不利于提高生长性能，但是与MON相比，EOC可以改善小牛的生长性能。