An efficient one-pot multicomponent reaction for the synthesis of novel tetrasubstituted hexahydroimidazo[1,2-a]pyridines starting from readily available cinnamaldehydes, ethylenediamines, and 1,3-dicarbonyl compounds catalyzed by AcOH is described. Two new cycles and four new bonds are constructed with all reactants being efficiently utilized in this transformation. The products could be obtained in 1–3 h under ambient conditions exclusively as a single isomer (trans). Single-crystal X-ray analysis confirmed the trans derivative as the only isomer.

中文翻译：

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在环境条件下通过一锅多组分反应轻松合成新型六氢咪唑并 [1,2-a] 吡啶衍生物。

描述了一种从容易获得的肉桂醛、乙二胺和 1,3-二羰基化合物开始，由 AcOH 催化合成新型四取代六氢咪唑并 [1,2- a ] 吡啶的有效一锅多组分反应。构建了两个新循环和四个新键，所有反应物都在此转化中得到了有效利用。在环境条件下，可以在 1-3 小时内以单一异构体（反式）形式获得产品。单晶 X 射线分析证实反式衍生物是唯一的异构体。