ABSTRACT

Cesium tungsten bronze nanoparticles have excellent near infrared lightresponse characteristics, easy surface modification and low cytotoxicity, which are attractive for tumor photothermal therapy. In this paper, cesium tungsten bronze nanoparticles were synthesized by a simple hydrothermal reaction method using cesium hydroxide as raw material. In order to improve the properties of dispersion and drug loading, the modification of two different surfactants was investigated. Themorphology of cesium tungsten bronze nanoparticles modified with polyvinylpyrrolidone had no significant change in scanning electron microscope, but it had high photothermal properties, with a photothermal conversion efficiency of 23.1%. The drug loading capacity of CTAB-Cs_0.32WO₃ is 47.9 mg/mL accordingly. The michigan cancer foundation-7 (MCF-7) cell activity was only 27.33% when the concentration of CTAB-Cs_0.32WO₃-DOX was 1mg/ml under irradiation of 980nm. These results showed that cesium tungsten bronze nanoparticles surface modified with hexadecyltrimethyl ammonium bromide (CTAB) had excellent anti-tumor ability.

摘要

铯钨青铜纳米粒子具有优异的近红外光响应特性、易于表面修饰和低细胞毒性，对肿瘤光热治疗具有吸引力。本文以氢氧化铯为原料，通过简单的水热反应法合成了铯钨青铜纳米粒子。为了改善分散性能和载药量，研究了两种不同表面活性剂的改性。聚乙烯吡咯烷酮改性铯钨青铜纳米粒子在扫描电镜下无明显变化，但具有较高的光热性能，光热转换效率为23.1%。CTAB-Cs的载药量_0.32 WO ₃ 相应地为 47.9 mg/mL。当CTAB-Cs _0.32 WO ₃ -DOX的浓度为1mg/ml时，在980nm的照射下，密歇根癌基金会-7（MCF-7）细胞活性仅为27.33% 。这些结果表明，十六烷基三甲基溴化铵（CTAB）表面修饰的铯钨青铜纳米粒子具有优异的抗肿瘤能力。