Abstract

Introduction

We aimed to determine the genetic polymorphisms and serum level of interleukin 18 in Fars ethnic groups.

Material and methods

226 Fars ethnic groups were participated. The ATP III criteria were used to assess MS components. The SNPs of the IL-18 gene were determined with ARMS-PCR.

Results

The GG, GC, and CC genotypes of −137 were 50%, 40%, and 10%. The CC, CA, and AA genotypes of −607 were 45%, 37%, and 18%. The GG, GC, and CC genotypes of −137 were 44.20%, 43.40%, and 12.40%, and were 55.75%, 36.28%, and 7.97% in subjects with and without MS, respectively. The CC, CA, and AA genotypes of −607 were 48.70%, 37.20%, and 14.20% and were 41.60%, 37.20%, and 21.20% in both groups, respectively.

Conclusion

IL-18 gene may different in specific populations, different ethnic groups and geographic regions. The IL-18 polymorphisms might not be used as a marker of metabolic syndrome.

中文翻译：

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伊朗北部代谢综合征法尔斯族群的遗传多态性-137 (G > C) (rs187238)和-607 (C > A) (rs1946518)和血清白细胞介素18水平

摘要

介绍

我们旨在确定 Fars 族群中白细胞介素 18 的遗传多态性和血清水平。

材料与方法

226个法尔斯族参加。ATP III 标准用于评估 MS 组件。IL-18基因的SNP用ARMS-PCR测定。

结果

-137 的 GG、GC 和 CC 基因型分别为 50%、40% 和 10%。-607 的 CC、CA 和 AA 基因型分别为 45%、37% 和 18%。-137 的 GG、GC 和 CC 基因型分别为 44.20%、43.40% 和 12.40%，在有和没有 MS 的受试者中分别为 55.75%、36.28% 和 7.97%。-607的CC、CA和AA基因型分别为48.70%、37.20%和14.20%，两组分别为41.60%、37.20%和21.20%。

结论

IL-18基因在特定人群、不同种族和地理区域可能存在差异。IL-18 多态性可能不能用作代谢综合征的标志物。