Abstract

Objective

The present study aimed to investigate the possible anti-neuropathic effects of daily pulsed magnetic field treatments (PMF) in streptozotocin (60 mg/kg) induced 4 weeks diabetic (type-1) wistar rats (6–8 months).

Materials and methods

Body mass, blood glucose and thermal and mechanical sensations were evaluated during the PMF or sham-PMF in diabetic or non-diabetic rats (n = 7/group). After the measurements of motor nerve conduction velocities (MNCV), the levels of several biomarkers for oxidative stress, apoptosis and angiogenesis in spinal cord and sciatic nerve were measured.

Results

PMF for 4 weeks significantly recovered the MCNV (96.9% and 63.9%) and almost fully (100%) restored to the latency and threshold. PMF also significantly suppressed the diabetes induced enhances in biochemical markers of both neuronal tissues.

Conclusions

Findings suggested that PMF might prevent the development of functional abnormalities in diabetic rats due to its anti-oxidative, anti-apoptotic and anti-angiogenic actions in neuronal tissues.

中文翻译：

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脉冲磁场治疗通过调节实验性糖尿病大鼠模型中的神经元氧化应激、细胞凋亡和血管生成来改善周围神经病变的进展

摘要

客观的

本研究旨在研究每日脉冲磁场治疗 (PMF) 在链脲佐菌素 (60 mg/kg) 诱导的 4 周糖尿病 (1 型) wistar 大鼠 (6-8 个月) 中可能的抗神经病变作用。

材料和方法

在糖尿病或非糖尿病大鼠（n = 7/组）的 PMF 或假 PMF 期间评估体重、血糖以及热和机械感觉。在测量运动神经传导速度（MNCV）后，测量了脊髓和坐骨神经中氧化应激、细胞凋亡和血管生成的几种生物标志物的水平。

结果

4 周的 PMF 显着恢复了 MCNV（96.9% 和 63.9%）并且几乎完全（100%）恢复到潜伏期和阈值。PMF 还显着抑制糖尿病引起的两种神经元组织的生化标志物的增强。

结论

研究结果表明，由于其在神经元组织中的抗氧化、抗凋亡和抗血管生成作用，PMF 可能会阻止糖尿病大鼠功能异常的发展。