ABSTRACT

The relationship between the interleukin-17F (IL-17F) rs763780 polymorphism and tuberculosis (TB) has been a source of debate. The potential association between the IL-17F rs763780 polymorphism and TB was investigated using a meta-analysis of case-control studies, which were obtained using the EMBASE, PubMed, CNKI, Scopus, and Web of Science databases. Heterogeneity across studies was evaluated, and summary odds ratios and 95% confidence intervals were computed to estimate a summary effect size using either a fixed-effects or random-effects model. Eight eligible studies comprising nine comparisons for the IL-17F rs763780 polymorphism (3824 cases and 3787 controls) were obtained for this meta-analysis. Although a significant relationship between IL-17F rs763780 and TB susceptibility was observed using the allele genetic model (odds ratio = 1.34, 95% confidence interval = 1.04–1.74), there was high heterogeneity among the studies (I2 = 79%, P=0.0001). The stratified analyses by race, type of tuberculosis, and Hardy–Weinberg equilibrium suggested that the IL-17F rs763780 polymorphism was not associated with risk of pulmonary tuberculosis and the heterogeneity disappeared. Hardy–Weinberg equilibrium is the main cause of the heterogeneity. No evidence was found through this meta-analysis that suggested an association between the IL-17F rs763780 polymorphism and risk of pulmonary tuberculosis.

摘要

白细胞介素-17F (IL-17F) rs763780 多态性与结核病 (TB) 之间的关系一直存在争议。使用 EMBASE、PubMed、CNKI、Scopus 和 Web of Science 数据库获得的病例对照研究的荟萃分析研究了 IL-17F rs763780 多态性与结核病之间的潜在关联。评估了研究之间的异质性，并计算了汇总优势比和 95% 置信区间，以使用固定效应或随机效应模型估计汇总效应大小。该荟萃分析获得了八项符合条件的研究，包括 IL-17F rs763780 多态性的九项比较（3824 例病例和 3787 例对照）。尽管使用等位基因遗传模型（优势比 = 1.34，95% 置信区间 = 1.04–1.74），研究之间存在高度异质性（I2 = 79%，P=0.0001）。按种族、结核病类型和 Hardy-Weinberg 平衡进行的分层分析表明，IL-17F rs763780 多态性与肺结核风险无关，异质性消失。Hardy-Weinberg 平衡是异质性的主要原因。通过这项荟萃分析没有发现任何证据表明 IL-17F rs763780 多态性与肺结核风险之间存在关联。Hardy-Weinberg 平衡表明 IL-17F rs763780 多态性与肺结核风险无关，异质性消失。Hardy-Weinberg 平衡是异质性的主要原因。通过这项荟萃分析没有发现任何证据表明 IL-17F rs763780 多态性与肺结核风险之间存在关联。Hardy-Weinberg 平衡表明 IL-17F rs763780 多态性与肺结核风险无关，异质性消失。Hardy-Weinberg 平衡是异质性的主要原因。通过这项荟萃分析没有发现任何证据表明 IL-17F rs763780 多态性与肺结核风险之间存在关联。