ABSTRACT

The association between Cadmium and the risk of preterm birth (PTB) has remained controversial. A number of studies found a positive correlation between maternal Cd exposure and PTB; however, there are conflicting reports about this correlation. Therefore, herein we performed this meta-analysis to examine the association between maternal Cd exposure and the risk of PTB.

A systematic search was conducted through PubMed, Scopus, Embase and OpenGrey from inception to May 2020 to find all eligible studies. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to examine this correlation. A random-effects model was applied in this meta-analysis due to significant statistical heterogeneity among included studies.

Overall, 10 eligible studies met the inclusion criteria and were included in our analysis, and results of the present meta-analysis indicated that maternal cadmium exposure is associated with the risk of PTB (OR = 1.32; 95% CI = 1.08–1.61).

This meta-analysis suggests that maternal Cd exposure might be associated with the risk of PTB. Yet, large prospective studies from different ethnic populations which consider other influencing parameters are still required to confirm this finding.

摘要

镉与早产风险 (PTB) 之间的关联仍然存在争议。多项研究发现母体 Cd 暴露与 PTB 呈正相关；然而，关于这种相关性的报道相互矛盾。因此，在此我们进行了这项荟萃分析，以检查母体 Cd 暴露与 PTB 风险之间的关联。

从成立到 2020 年 5 月，通过 PubMed、Scopus、Embase 和 OpenGrey 进行了系统搜索，以找到所有符合条件的研究。优势比 (OR) 和相应的 95% 置信区间 (CI) 用于检查这种相关性。由于纳入研究之间存在显着的统计学异质性，本荟萃分析采用了随机效应模型。

总体而言，10 项符合条件的研究符合纳入标准并被纳入我们的分析，目前的荟萃分析结果表明，母体镉暴露与 PTB 风险相关（OR = 1.32；95% CI = 1.08-1.61）。

这项荟萃分析表明，母体 Cd 暴露可能与 PTB 的风险相关。然而，仍然需要来自不同种族人群并考虑其他影响参数的大型前瞻性研究来证实这一发现。