Polyherbal Formulations (PHF) were developed by combining fruit juices of Momordica charantia, Cucumis sativus, and Solanum lycopersicum in different ratios and optimized through Oral Glucose Tolerance Test (OGTT) model. PHF‐C pretreated rats showed the highest reduction of Serum Glucose Levels (SGL) after 60 min of glucose administration. PHF‐C was incorporated into spheroids using fresh juice (FJS) and lyophilized powder (LPS) of selected plants. In OGTT study, LPS showed a significant reduction of SGL. LPS was characterized as almost spherical, having disintegration time 8 min, adequate friability, and good flow properties. In STZ‐induced diabetic rats on 7th, 14th, and 21st days, LPS was reduced SGL by 9.01%, 20.9%, 38.9% (250 mg/kg dose); 20.5%, 33.9%, and 50.7% (500 mg/kg dose), respectively. LPS showed a significant improvement in abnormal body weight, biochemical, and oxidative parameters in comparison to PHF‐C and metformin. Novel formulation LPS (500 mg/kg) was found more effective (p < .05) in reversing STZ‐induced hyperglycemia as compared to PHF‐C (1,000 mg/kg) and at par with metformin (500 mg/kg).

中文翻译：

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新鲜蔬菜汁中球形抗糖尿病多草药配方的开发和表征：一种新方法

通过结合苦瓜，黄瓜，黄瓜和茄子的果汁开发出多草药配方（PHF）并通过口服葡萄糖耐量测试（OGTT）模型进行了优化。服用PHF-C的大鼠在服用葡萄糖60分钟后显示出最高的血清葡萄糖水平（SGL）降低。使用选定植物的新鲜果汁（FJS）和冻干粉（LPS）将PHF-C掺入球体中。在OGTT研究中，LPS显示SGL明显降低。LPS的特征是几乎球形，具有8分钟的崩解时间，足够的脆性和良好的流动性。在STZ诱导的糖尿病大鼠的第7、14和21天，LPS降低SGL分别为9.01％，20.9％，38.9％（250 mg / kg剂量）；500 mg / kg剂量分别为20.5％，33.9％和50.7％。与PHF-C和二甲双胍相比，LPS在异常体重，生化和氧化参数方面显示出显着改善。 与PHF-C（1,000 mg / kg）相比，STZ诱发的高血糖逆转（p <.05），与二甲双胍（500 mg / kg）相当。