The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide‐binding domain and leucine‐rich repeat receptor family members CIITA and NLRC5 function as the major transcriptional activators of MHC class II and class I gene expression, respectively. Since the identification of NLRC5 as the master regulator of MHC class I and class‐I‐related genes, there have been major advances in understanding the function of NLRC5 in infectious diseases and cancer. Here, we discuss the biological significance and mechanism of NLRC5‐dependent MHC class I expression.

中文翻译：

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MHC I 类反式激活因子 NLRC5 在宿主免疫、癌症及其他方面

主要组织相容性复合体 (MHC) I 类和 II 类分子呈递抗原肽对于激活适应性免疫系统至关重要。核苷酸结合域和富含亮氨酸的重复受体家族成员 CIITA 和 NLRC5 分别作为 MHC II 类和 I 类基因表达的主要转录激活因子。自从 NLRC5 被鉴定为 MHC I 类和 I 类相关基因的主要调节因子以来，在了解 NLRC5 在传染病和癌症中的功能方面取得了重大进展。在这里，我们讨论了 NLRC5 依赖性 MHC I 类表达的生物学意义和机制。