Monohydroxylated polycyclic aromatic hydrocarbons (OH-PAHs), phthalate metabolites (mPAEs), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the urine of school children aged 8–11 years from Shenzhen, China were measured in order to investigate oxidative stress damage from co-exposure to PAHs and PAEs. The concentrations of OH-PAHs and mPAEs in urine were 0.36–36.5 (median: 3.86) and 9.48–1609 (median: 240) ng/mL respectively. Gender and age did not influence urinary concentrations of ΣOH-PAHs and ΣmPAEs, but geographical variations (i.e., urban versus suburban) were observed. Levels of 8-OHdG were positively correlated with urinary OH-PAHs and mPAEs, with correlation coefficients (r) varying between 0.160 and 0.365 (p < 0.05). OH-PAHs made a greater contribution to oxidative DNA damage than mPAEs when these two types of pollutants were present at the same concentrations. Human health risks were assessed using the hazard quotient and the hazard index for the cumulative risk of a complex of chemicals. The results demonstrated that risks from PAHs could be neglected, but that 29.5 % of school children may be subject to obvious health risks from PAEs, especially diethylhexyl phthalate.

对深圳的8-11岁学龄儿童的尿液中的单羟基化多环芳烃（OH-PAHs），邻苯二甲酸酯代谢物（mPAEs）和8-羟基-2'-脱氧鸟苷（8-OHdG）进行了测定，以便研究共同暴露于PAHs和PAEs对氧化应激的损害。尿液中的OH-PAHs和mPAEs浓度分别为0.36–36.5（中位数：3.86）和9.48–1609（中位数：240）ng / mL。性别和年龄不影响ΣOH-PAHs和ΣmPAE的尿液浓度，但观察到地理差异（即城市与郊区）。8-OHdG水平与尿中OH-PAH和mPAE呈正相关，相关系数（r）在0.160和0.365之间变化（p <0.05）。当两种污染物以相同的浓度存在时，OH-PAHs对氧化DNA损伤的贡献要大于mPAE。使用危害因子和危害指数来评估复杂化学品的累积风险对人类健康的危害。结果表明，PAHs的风险可以忽略，但是29.5％的小学生可能会明显受到PAEs的健康风险，尤其是邻苯二甲酸二乙基己酯。