Base excision repair addresses the numerous base lesions and strand breaks induced by exogenous and endogenous stressors daily. The complexity and importance of BER requires careful regulation of basal levels of these proteins and inducible responses following DNA damage. Several reports have noted the dysregulation of BER proteins and defects in BER capacity in cancer. Modulated gene and protein expression of several BER proteins, including APE1, PARP1, POL β, and XRCC1, have been observed in breast cancer. Overexpression of these factors has been associated with chemoresistance and cancer aggressiveness, but the regulatory mechanisms that drive overexpression have not been defined. Here, we review the known transcriptional regulators of these key BER proteins and examine potential mechanisms that may drive overexpression in breast cancer.

基础切除修复解决了每天由外源性和内源性应激源引起的众多基础病变和链断裂。BER的复杂性和重要性要求仔细调节这些蛋白质的基础水平以及DNA损伤后的诱导反应。几篇报道指出了BER蛋白的失调和癌症BER能力的缺陷。在乳腺癌中已经观察到几种BER蛋白的调节基因和蛋白表达，包括APE1，PARP1，POLβ和XRCC1。这些因素的过表达与化学抗性和癌症侵袭性有关，但尚未定义驱动过表达的调节机制。在这里，我们审查这些关键的BER蛋白的已知的转录调节剂，并检查可能导致乳腺癌过度表达的潜在机制。