Coordination Chemistry Reviews ( IF 20.6 ) Pub Date : 2020-07-07 , DOI: 10.1016/j.ccr.2020.213460 Ya-Lin Qi , Long Guo , Li-Li Chen , Hua Li , Yu-Shun Yang , Ai-Qin Jiang , Hai-Liang Zhu
As one of the most representative hypoxic enzymes, nitroreductases (NTRs) play momentous roles in malignant tumor progression, metastasis, invasion and angiogenesis. They are also a key hallmark of highly aggressive disease in various hypoxic tumor cells. In addition, NTRs participate in essential processes of detoxification, pro-drug activation as well as radiation therapy. Thus, the detection of NTRs has great importance for theranostic and drug development. In this review, we focused on the design principles, sensing mechanisms and biological applications of small-molecule probes for NTRs detection over the past ten years (2010–2020). We also highlighted the challenges and future directions in this rapidly developing field. Significantly, we hope that some insights and inspiration for future research work will be provided to surmount the Achilles’ Heels of the small-molecule probes, such as limited application, for detecting NTRs.
中文翻译:
硝基还原酶小分子探针的设计原理,传感机理和应用的最新进展
作为最具代表性的缺氧酶之一,硝基还原酶(NTR)在恶性肿瘤的进展,转移,侵袭和血管生成中起着重要的作用。它们也是各种低氧肿瘤细胞中高度侵袭性疾病的关键标志。此外,NTRs参与排毒,前药激活以及放射治疗等基本过程。因此,NTRs的检测对于治疗学和药物开发非常重要。在这篇综述中,我们重点介绍了过去十年(2010-2020年)用于检测NTR的小分子探针的设计原理,传感机制和生物学应用。我们还强调了这个快速发展领域中的挑战和未来方向。重要的是