The thermodynamic and acoustic studies for well-known flavonoid; quercetin with an anionic surfactant sodium dodecyl sulfate (SDS) have been reported. The properties of micellar systems exhibiting various hydrophobic and hydrophilic interactions have been studied. The studies were performed in four different hydro-ethanolic concentrations i.e., aqueous, 30% v/v, 70% v/v and absolute ethanol at five different temperatures (293.15 K to 313.15 K with a difference of 5 K). Various parameters such as conductivity (κ), density (ρ), ultrasonic sound velocity (μ) and relative viscosity (η_r) were determined and resulting data was used to calculate the thermodynamic and acoustic parameters, namely, standard enthalpy change (ΔH^o_m), standard entropy change (ΔS^o_m), standard Gibbs energy change (ΔG^o_m) of micellization, apparent molar volume (ϕ_v) and apparent molar compressibility (ϕ_k). Moreover, ¹H NMR spectroscopic analysis of SDS and micelles was performed in order to confirm the location of quercetin in micellar structure of surfactant. These studies are helpful in investigating the extent of hydrophobic interactions within the system which might be utilized in determining a stable flavonoid-surfactant concentration in preparing pharmaceutical formulations.

著名类黄酮的热力学和声学研究；槲皮素与阴离子表面活性剂十二烷基硫酸钠（SDS）的关系已有报道。已经研究了表现出各种疏水和亲水相互作用的胶束系统的性质。研究是在五个不同温度（293.15 K至313.15 K，相差5 K）下，在四种不同的乙醇浓度下进行的，即水溶液，30％v / v，70％v / v和无水乙醇。各种参数，如导率（κ），密度（ρ），超声波声速（μ）和相对粘度（η _{- [R} ）测定并使用得到的数据来计算的热力学和声学参数，即，标准焓变（ΔH ^Ò_米），标准熵变（ΔS ^Ò_米），标准吉布斯自由能变化（ΔG ^ö_米）胶束的，表观摩尔体积（φ _v）和表观摩尔可压缩性（φ _ķ）。此外，为了确定槲皮素在表面活性剂的胶束结构中的位置，对SDS和胶束进行了¹ H NMR光谱分析。这些研究有助于研究系统中疏水相互作用的程度，该程度可用于确定制备药物制剂时稳定的类黄酮表面活性剂浓度。