The abundance of dietary sweeteners and overconsumption of fructose are widely thought to promote metabolic disease. In this issue of Cell Metabolism, Andres-Hernando et al. (2020) identify the liver as the major site of fructose metabolism-mediated metabolic dysfunction and identify a surprising role for intestinal fructose metabolism in driving fructose intake.

中文翻译：

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找到最佳结合点：解析果糖代谢的组织特异性贡献。

人们普遍认为，膳食甜味剂的丰富和果糖的过度消费会促进代谢性疾病。在本期《细胞代谢》一书中，Andres-Hernando等人。（2020）确定肝脏是果糖代谢介导的代谢功能障碍的主要部位，并确定肠果糖代谢在驱动果糖摄入方面具有令人惊讶的作用。