Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A limiting factor when considering therapies for the nervous tissue is the presence of the blood–brain barrier which stimulates the search for new drug delivery strategies. In this context, nanoencapsulation seems to be a promising alternative. In this work, we compared the protective effects of free and nanoemulsified curcumin after intracerebral haemorrhage induced by collagenase (ICH) in Wistar rats. Injury area, motor activity, oxidative stress in the brain and serum biochemical parameters were investigated. Two hours after surgery, the first dose was injected intraperitoneally, followed by 24 and 48 h administration. Behavioural analysis was performed through 3 different tests: open field, beam walking and foot fault (24, 48 and 72 h respectively). At the end of the recovering time (3 days after injury), the animals were euthanized and the brain (for analysis of injury area and oxidative stress), blood (for biochemical parameters), kidney and liver (for histopathological examination) were investigated. Curcumin nanoemulsion 30 mg/kg was able to improve behavioural recovery, reduce the size of the haematoma and attenuate the weight loss caused by ICH. In terms of oxidative parameters, we observed that curcumin nanoemulsion modulated antioxidant responses with therapeutic potential against ICH. Only discrete results in few parameters were found with free-curcumin in the same dose.

脑血管疾病是目前全球性的重大健康问题。考虑到当前疗法的局限性，有必要寻找治疗这些疾病的新替代品，在这种情况下，姜黄素是一种具有神经保护特性的分子，已在文献中描述过。考虑对神经组织进行治疗时的一个限制因素是血脑屏障的存在，这会刺激寻找新的药物递送策略。在这种情况下，纳米封装似乎是一个有前途的替代方案。在这项工作中，我们比较了游离和纳米乳化姜黄素在Wistar胶原酶（ICH）诱导的脑出血后的保护作用老鼠。研究了损伤区域、运动活动、大脑中的氧化应激和血清生化参数。手术后两小时，第一剂腹腔注射，随后24和48小时给药。行为分析通过 3 种不同的测试进行：开阔场地、横梁行走和足部故障（分别为 24、48 和 72 小时）。在恢复时间结束时（受伤后 3 天），对动物实施安乐死，并研究大脑（用于分析损伤区域和氧化应激）、血液（用于生化参数）、肾脏和肝脏（用于组织病理学检查）。姜黄素纳米乳 30 mg/kg 能够改善行为恢复，减少血肿的大小并减轻 ICH 引起的体重减轻。在氧化参数方面，我们观察到姜黄素纳米乳调节抗氧化反应，具有治疗 ICH 的潜力。在相同剂量的游离姜黄素中，仅发现少数参数的离散结果。