The flow behavior of blood is determined mainly by red blood cell (RBC) deformation and aggregation as well as blood viscoelasticity. These intricately interdependent parameters should be monitored by healthcare providers to understand all aspects of circulatory flow dynamics under numerous cases including cardiovascular and infectious diseases. Current medical instruments and microfluidic systems lack the ability to quantify these parameters all at once and in physiologically relevant flow conditions. This work presents a handheld platform and a measurement method for quantitative analysis of multiple of these parameters from 50 μl undiluted blood inside a miniaturized channel. The assay is based on an optical transmission analysis of collective RBC deformation and aggregation under near-infrared illumination during a 1 s damped oscillatory flow and at stasis, respectively. Measurements with blood of different hemo-rheological properties demonstrate that the presented approach holds a potential for initiating simultaneous and routine on-chip blood flow analysis even in resource-poor settings.

中文翻译：

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使用振荡流下的红细胞动力学体外分析多种血流决定因素。

血液的流动行为主要取决于红细胞（RBC）的变形和聚集以及血液的粘弹性。这些错综复杂的相互依赖的参数应由医疗保健提供者进行监控，以了解在包括心血管疾病和传染性疾病在内的多种情况下循环血流动力学的各个方面。当前的医疗仪器和微流体系统缺乏在生理上相关的流动条件下一次量化这些参数的能力。这项工作提出了一个手持平台和一种测量方法，用于对微型通道内50μl未稀释血液中的多个参数进行定量分析。该测定基于分别在1 s阻尼振荡流和静止状态下在近红外光照射下集体RBC变形和聚集的光学透射分析。使用具有不同血液流变特性的血液进行的测量表明，即使在资源贫乏的环境中，所提出的方法也有可能启动同时进行的常规片上血流分析。