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RNA interference in glial cells for nerve injury treatment.
Journal of Tissue Engineering ( IF 8.2 ) Pub Date : 2020-07-06 , DOI: 10.1177/2041731420939224
Junquan Lin 1 , Seung Bin Jo 2 , Tae-Hyun Kim 2, 3 , Hae-Won Kim 2, 3, 4 , Sing Yian Chew 1, 5
Affiliation  

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.



中文翻译:

RNA干扰神经胶质细胞治疗神经损伤。

RNA干扰的驱动器对于操纵基因和蛋白质水平很有效,这可以恢复通常与伤害和疾病相关的失调的mRNA表达。这篇综述总结了利用RNA干扰靶向神经胶质细胞治疗中枢神经系统持续神经损伤的潜力。另外,将讨论递送这些RNA干扰效应子的各种方法。

更新日期:2020-07-06
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