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The Role of Glypicans in Cancer Progression and Therapy.
Journal of Histochemistry & Cytochemistry ( IF 3.2 ) Pub Date : 2020-07-06 , DOI: 10.1369/0022155420933709
Nan Li 1 , Madeline R Spetz 1 , Mitchell Ho 1
Affiliation  

Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple ligands, including morphogens, growth factors, chemokines, ligands, receptors, and components of the extracellular matrix through their heparan sulfate chains and core protein. Therefore, glypicans can function as coreceptors to regulate cell proliferation, cell motility, and morphogenesis. In addition, some glypicans are abnormally expressed in cancers, possibly involved in tumorigenesis, and have the potential to be cancer-specific biomarkers. Here, we provide a brief review focusing on the expression of glypicans in various cancers and their potential to be targets for cancer therapy.



中文翻译:

Glypicans 在癌症进展和治疗中的作用。

Glypicans 是硫酸乙酰肝素蛋白聚糖家族,通过糖基磷脂酰肌醇锚附着在细胞膜上。Glypicans 通过其硫酸乙酰肝素链和核心蛋白与多种配体相互作用,包括形态发生素、生长因子、趋化因子、配体、受体和细胞外基质的成分。因此,glypicans 可以作为辅助受体来调节细胞增殖、细胞运动和形态发生。此外,一些磷脂酰肌醇蛋白聚糖在癌症中异常表达,可能与肿瘤发生有关,并有可能成为癌症特异性生物标志物。在这里,我们简要回顾了磷脂酰肌醇蛋白聚糖在各种癌症中的表达及其成为癌症治疗靶点的潜力。

更新日期:2020-07-06
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