ABSTRACT

1. Dulong Chickens (DLCs) live at high altitude (~3000 m) and humidity (~90%), are endemic to the Yunnan province, and have gradually developed unique physiological characteristics, but their genetic basis is still unclear. Using the fixation index (F_ST ) approach, based on whole-genome resequencing, DLCs were analysed to uncover the genomic architecture of the population and candidate genes involved in selection during domestication.

2. A total of 469 candidate genes were obtained to be putatively under selection in DLCs. Further investigations revealed the genic footprint for local adaptation (high-altitude and high-humidity) as the genic signatures that are involved in economic traits (related to egg production).

3. Candidate genes were identified that may be associated with disease resistance, aggressiveness, small body size and positive selection of vision in DLCs.

4. These data revealed loci of selective signals that operate during selection for production at high altitude and humidity.

摘要

1.独龙鸡（DLC）生活在高海拔（〜3000 m）和高湿度（〜90％）处，是云南省特有的，并已逐渐发展出独特的生理特征，但其遗传基础仍不清楚。使用固定指数（F _ST ）方法，基于全基因组重测序，对DLC进行了分析，以揭示种群的基因组结构和驯化过程中参与选择的候选基因。

2.共有469个候选基因被推定为在DLC中进行选择。进一步的研究表明，当地适应（高海拔和高湿度）的基因足迹是涉及经济性状（与产蛋相关）的基因特征。

3.鉴定了可能与DLC中的疾病抗性，侵略性，小体形和正视选择有关的候选基因。

4.这些数据揭示了选择信号的位点，这些信号在选择过程中在高海拔和高湿度下生产。