We analysed data from 80 patients who tested positive for SARS‐CoV‐2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA‐ DQB1*06 (53% vs. 36%; p < .012; OR 1.96; 95% CI 1.94–3.22) and infection. A bias towards an increased representation of HLA‐A*26, HLA‐DRB1*15, HLA‐DRB1*10 and DRB1*11 was also noted but these were either only significant using the UK donor controls, or did not remain significant after correction for multiple tests. Likewise, HLA‐A*02, HLA‐B*44 and HLA‐C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests. This is relevant information for the clinical management of patients in the setting of the current SARS‐CoV‐2 pandemic and potentially in risk‐assessing staff interactions with infected patients.

中文翻译：

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在移植患者中观察到人类白细胞抗原在 SARS-Cov-2 感染易感性中的作用

我们分析了 80 名 SARS-CoV-2 RNA 检测呈阳性的患者的数据，这些患者之前进行了 HLA 分型以支持移植。数据来自曼彻斯特和利兹的两个相邻中心，以获得足够的早期分析数据。将观察到的 HLA 频率与两个对照人群进行比较：首先，与代表病毒目标人群的英国已故供体人群（n = 10,000）中公布的频率进行比较，其次，使用来自两者的联合移植等待名单中的一组个体中心（n = 308），代表相同人口统计的未受影响个体的比较组。我们报告了与 HLA-DQB1*06 显着相关的 HLA（53% 对 36%；p < .012；OR 1.96；95% CI 1.94–3.22）和感染。倾向于增加 HLA-A*26、HLA-DRB1*15、还注意到 HLA-DRB1*10 和 DRB1*11，但这些要么仅在使用英国供体对照时才显着，要么在经过多次测试校正后仍不显着。同样，HLA-A*02、HLA-B*44 和 HLA-C*05 可能发挥保护作用，但在多次测试校正后，这些关联并不显着。这是在当前 SARS-CoV-2 大流行的背景下对患者进行临床管理的相关信息，并可能用于风险评估工作人员与受感染患者的互动。