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Bilayer Cylindrical Conduit Consisting of Electrospun Polycaprolactone Nanofibers and DSC Cross-Linked Sodium Alginate Hydrogel to Bridge Peripheral Nerve Gaps.
Macromolecular Bioscience ( IF 4.6 ) Pub Date : 2020-07-06 , DOI: 10.1002/mabi.202000149 Neshat Askarzadeh 1 , Masoumeh Haghbin Nazarpak 2 , Korosh Mansoori 3 , Mehdi Farokhi 4 , Mahdi Gholami 5 , Javad Mohammadi 1 , Fatemeh Mottaghitalab 6
Macromolecular Bioscience ( IF 4.6 ) Pub Date : 2020-07-06 , DOI: 10.1002/mabi.202000149 Neshat Askarzadeh 1 , Masoumeh Haghbin Nazarpak 2 , Korosh Mansoori 3 , Mehdi Farokhi 4 , Mahdi Gholami 5 , Javad Mohammadi 1 , Fatemeh Mottaghitalab 6
Affiliation
Herein, a bilayer cylindrical conduit (P‐CA) is presented consisting of electrospun polycaprolactone (PCL) nanofibers and sodium alginate hydrogel covalently cross‐linked with N,N′‐disuccinimidyl carbonate (DSC). The bilayer P‐CA conduit is developed by combining the electrospinning and outer–inner layer methods. Using DSC, as a covalent crosslinker, increases the degradation time of the sodium alginate hydrogel up to 2 months. The swelling ratio of the hydrogel is also 503% during the first 8 h. The DSC cross‐linked sodium alginate in the inner layer of the conduit promotes the adhesion and proliferation of nerve cells, while the electrospun PCL nanofibers in the outer layer provide maximum tensile strength of the conduit during surgery. P‐CA conduit promotes the migration of Schwann cells along the axon in a rat model based on functional and histological evidences. In conclusion, P‐CA conduit will be a promising construct for repairing sciatic nerves in a rat model.
中文翻译:
由电纺聚己内酯纳米纤维和 DSC 交联海藻酸钠水凝胶组成的双层圆柱形导管,用于桥接外周神经间隙。
在此,提出了一种双层圆柱形导管(P-CA),由电纺聚己内酯(PCL)纳米纤维和与 N,N'-二琥珀酰亚胺碳酸酯(DSC)共价交联的海藻酸钠水凝胶组成。双层 P-CA 导管是通过结合静电纺丝和外-内层方法开发的。使用 DSC 作为共价交联剂,可将海藻酸钠水凝胶的降解时间延长至 2 个月。在前 8 小时内,水凝胶的溶胀率也是 503%。导管内层的 DSC 交联海藻酸钠促进了神经细胞的粘附和增殖,而外层的电纺 PCL 纳米纤维在手术过程中提供了导管的最大拉伸强度。基于功能和组织学证据,P-CA 导管促进大鼠模型中雪旺氏细胞沿轴突迁移。总之,P-CA 导管将是修复大鼠模型坐骨神经的有前途的结构。
更新日期:2020-07-06
中文翻译:
由电纺聚己内酯纳米纤维和 DSC 交联海藻酸钠水凝胶组成的双层圆柱形导管,用于桥接外周神经间隙。
在此,提出了一种双层圆柱形导管(P-CA),由电纺聚己内酯(PCL)纳米纤维和与 N,N'-二琥珀酰亚胺碳酸酯(DSC)共价交联的海藻酸钠水凝胶组成。双层 P-CA 导管是通过结合静电纺丝和外-内层方法开发的。使用 DSC 作为共价交联剂,可将海藻酸钠水凝胶的降解时间延长至 2 个月。在前 8 小时内,水凝胶的溶胀率也是 503%。导管内层的 DSC 交联海藻酸钠促进了神经细胞的粘附和增殖,而外层的电纺 PCL 纳米纤维在手术过程中提供了导管的最大拉伸强度。基于功能和组织学证据,P-CA 导管促进大鼠模型中雪旺氏细胞沿轴突迁移。总之,P-CA 导管将是修复大鼠模型坐骨神经的有前途的结构。