To propose a correlation between polyneuropathy and ATTRwt based on retrospective analysis of patients with ATTRwt. We reviewed 151 ATTRwt patients followed by the amyloid cardiac clinic (group A) for symptoms of neuropathy and 12 patients with ATTRwt evaluated in the Neurology Department (group B) with objective measures of neuropathy. Medical history, electrodiagnosis, laboratory and skin biopsies were assessed; 30.5% of group A had neuropathy symptoms. Alternative explanations for neuropathy symptoms were explored, including, age, gender, BMI, diabetes mellitus, B12 deficiency. No difference was observed for BMI, age, gender and spine disease for those with and without neuropathic symptoms (P > .05). All of group B (n = 12) were diagnosed with neuropathy, confirmed by electrodiagnostic testing or skin biopsy, while two patients had not yet developed cardiac symptoms. We observe a higher prevalence of neuropathic symptoms in ATTRwt patients than previously believed. Neuropathic symptoms may precede cardiac symptoms. Our findings suggest a possible causative relationship that requires further investigation.

中文翻译：

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野生型转甲状腺素蛋白淀粉样变性的周围神经病变症状。

基于对 ATTRwt 患者的回顾性分析，提出多发性神经病与 ATTRwt 之间的相关性。我们回顾了 151 名 ATTRwt 患者，随后在淀粉样心脏诊所（A 组）评估了神经病变的症状，并在神经科（B 组）中对 12 名 ATTRwt 患者进行了神经病变的客观评估。对病史、电诊断、实验室和皮肤活检进行了评估；A组30.5%的人有神经病变症状。探讨了神经病变症状的其他解释，包括年龄、性别、BMI、糖尿病、维生素 B12 缺乏症。有和无神经性症状者的BMI、年龄、性别和脊柱疾病均无差异（P> .05）。B组（n = 12）均被诊断为神经病变，经电诊断测试或皮肤活检证实，而两名患者尚未出现心脏症状。我们观察到 ATTRwt 患者神经性症状的患病率比以前认为的更高。神经性症状可能先于心脏症状。我们的研究结果表明可能存在因果关系，需要进一步调查。