Keratin (Ker) protein regenerated from readily available and low-cost wastes (e.g. raw wool, feathers and textile by-products) is a promising natural polymer for tissue engineering and drug delivery.

Nevertheless, while showing good bioactivity and great drug carrier properties, keratin lacks of suitable mechanical characteristics. To overcome this drawback, keratin was blended with poly(butylene succinate) (PBS), a biodegradable and biocompatible polyester able to confer mechanical integrity to the keratin based materials.

Despite the poor compatibility at the molecular level between keratin and PBS, their 50-50 blends were successfully electrospun into manageable mats, made of randomly oriented nanofibers with mean diameter of 290 nm. Along with mechanical properties, PBS improves also the thermal stability of the keratin based nanofibrous mats. On the other hand, compared to PBS-only electrospun mats, the presence of keratin improves both swelling ability and biodegradability and amplifies the capacity of drug release as well as fibroblast proliferation of the blend mat.

从容易获得的低成本废物（例如原毛，羽毛和纺织品副产品）中再生的角蛋白（Ker）蛋白是用于组织工程和药物输送的有前途的天然聚合物。

然而，尽管角蛋白显示出良好的生物活性和良好的药物载体性质，但缺乏合适的机械特性。为了克服此缺点，将角蛋白与聚丁二酸丁二酯（PBS）混合，聚丁二酸丁二酯（PBS）是一种可生物降解的生物相容性聚酯，能够为角蛋白基材料提供机械完整性。

尽管角蛋白和PBS在分子水平上的相容性很差，但它们的50-50掺混物已成功地电纺成易于管理的垫子，该垫子由平均直径为290 nm的随机取向的纳米纤维制成。PBS不仅具有机械性能，而且还改善了基于角蛋白的纳米纤维垫的热稳定性。另一方面，与仅PBS的电纺垫相比，角蛋白的存在改善了溶胀能力和生物降解性，并增强了药物的释放能力以及混合垫的成纤维细胞增殖能力。