Nowadays, enantioseparation of racemic pharmaceuticals in preparations is a prime concern by drug authorities across the globe. In the present work, it was attempted to develop novel enantioselective extraction method for five clinically used drugs (atenolol, propranolol, metoprolol, racecadotril, and raceanisodamine in their tablets) as racemates. The enantioselective solid-liquid extraction of these racemic drugs was carried out successfully by the use of chiral ionic liquid (CIL) in combination with a metal organic framework (MOF) for the first time. The composite CIL@MOF was synthesized from tropine based chiral ionic liquids with L-proline anion ([C_nTr][L-Pro], n=3–6) and HKUST-1 type MOF, which was comprehensively characterized before being used as sorbent for enantioselective dispersive solid-liquid extraction. Preliminary selection of appropriate CIL was carried out on thin layer chromatography (TLC); under the joint participation of copper ion in the developing reagent, [C₃Tr][L-Pro] ionic liquid showed better resolution performance with ΔR_f value of 0.35 between the enantiomers was obtained for racemic atenolol. Moreover, the effect of copper salt dosage, amount of CIL, soli-liquid ratio and extraction time were investigated. The optimal conditions were obtained after thorough investigations; i.e. sample solution: ethanol, elution solvent: methanol, solid-liquid ratio: 12.5 mg:50 mL, amount of copper salt: 8 mg L⁻¹, amount of impregnated CIL: 30% and extraction time of 30 min. As a result, enantiomeric excess values are 90.4%, 95%, 92%, 81.6% and 83.2% for atenolol, propranolol, metoprolol, racecadotril and raceanisodamine, respectively. The developed enantioselective method was validated following ICH guidelines and it was proved to be simple, effective and enantioselective way for separation of racemic pharmaceuticals with similar behaviors.

如今，制剂中外消旋药物的对映体分离已成为全球药物管理局关注的首要问题。在目前的工作中，试图开发出作为消旋体的五种临床使用药物（片剂中的阿替洛尔，普萘洛尔，美托洛尔，消旋卡多曲和消旋苯乙胺）的新型对映选择性提取方法。通过将手性离子液体（CIL）与金属有机骨架（MOF）结合使用，成功地对这些外消旋药物进行了对映选择性固液萃取。复合化合物CIL @ MOF是由基于tropine的手性离子液体与L-脯氨酸阴离子（[C _n Tr] [L-Pro]，n= 3-6）和HKUST-1型MOF，在用作对映选择性分散固液萃取的吸附剂之前已进行了全面表征。适当的CIL的初步选择是在薄层色谱（TLC）上进行的。铜离子在显影试剂的共同参与下，[C ₃ TR] [L-Pro的]离子液体显示出与ΔR更好的分辨率性能_˚F的对映异构体之间的0.35值外消旋阿替洛尔获得。此外，研究了铜盐用量，CIL量，固液比和萃取时间的影响。经过深入研究，获得了最佳条件。即样品溶液：乙醇，洗脱溶剂：甲醇，固液比：12.5 mg：50 mL，铜盐量：8 mg L ^-1，浸渍的CIL量：30％，提取时间为30分钟。结果，替丁洛尔，普萘洛尔，美托洛尔，消旋卡多曲和消旋苯胺多胺的对映体过量值分别为90.4％，95％，92％，81.6％和83.2％。遵循ICH指南验证了开发的对映选择性方法，并且证明了分离具有相似行为的外消旋药物的简单，有效和对映选择性的方法。