The literature comprehensively analyzed alternative splicing (AS) events in colon cancer is little and corresponding prognostic signature is still a lack. Based on data of TCGA, the relapse-associated ASs were comprehensively analyzed and a signature was further constructed to predict the relapse in I–III colon cancer. In total 1912 ASs of 1384 mRNA were identified as relapse-associated ASs, protein-protein interactions (PPI) and ASs-splicing factors (SF) interactions network were identified. We finally built a robust signature to predict the relapse of I–III colon cancer with a considerable AUC value in both the training group and the test group. The AUC in the entire set at 1, 3 and 5 year was 0.85, 0.83 and 0.836. Our study provided a profile of relapse-associated ASs in I–III colon cancer and built a robust signature to predict the relapse of I–III colon cancer.

综合分析结肠癌中选择性剪接（AS）事件的文献很少，并且仍然缺乏相应的预后特征。基于TCGA的数据，综合分析了与复发相关的AS，并进一步构建了一个特征来预测I-III期结肠癌的复发。共有 1384 个 mRNA 中的 1912 个 ASs 被鉴定为复发相关的 ASs，蛋白质-蛋白质相互作用（PPI）和 ASs-剪接因子（SF）相互作用网络被确定。我们最终建立了一个强大的特征来预测 I-III 结肠癌的复发，在训练组和测试组中都有相当大的 AUC 值。1、3、5年全组AUC分别为0.85、0.83、0.836。