Phthalates and bisphenol A, to which people are mainly exposed through food, interfere with the body's endocrine system, along with various other toxic effects. Literature data suggest that probiotic cultures might be able to decrease the adverse effects of toxic substances by various mechanisms. The aim of this study was to investigate if treatment with multi-strained probiotic could reduce the toxicity of phthalates and bisphenol A mixture in Wistar rats. Animals were divided into four experimental groups (n = 6): (1) Control (corn oil); (2) P (probiotic (8.78 * 10⁸ CFU/kg/day): Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus planarum LP 6595+ Lactobacillus planarum HEAL9); (3) MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA); (4) MIX + P. Animals were euthanized after 28 days of daily oral gavage treatment; blood and organs were collected for further analysis. Probiotic reduced systemic inflammation and had protective effects on liver, kidneys, spleen, lipid status and serum glucose level. It almost completely annulled the changes in biochemical, hematological and hormonal parameters and mitigated changes in relative liver size, food consumption and organ histology. These results suggest considering multi-strained probiotics as a dietary therapeutic strategy against toxicity of the investigated mixture.

人们主要通过食物接触的邻苯二甲酸盐和双酚A会干扰人体的内分泌系统，并产生其他各种毒性作用。文献数据表明，益生菌培养物可能能够通过各种机制减少有毒物质的不利影响。这项研究的目的是研究用多菌株益生菌治疗是否可以降低Wistar大鼠中邻苯二甲酸酯和双酚A混合物的毒性。将动物分为四个实验组（n = 6）：（1）对照（玉米油）；（2）P（益生菌（8.78 * 10 ⁸  CFU / kg /天）：酿酒酵母 + 鼠李糖乳杆菌 + 平面乳杆菌LP 6595+平面乳杆菌HEAL9）; （3）混合（50 mg / kg bw /天DEHP + 50 mg / kg bw /天DBP + 25 mg / kg bw /天BPA）; （4）MIX + P。每天经管饲法治疗28天后对动物实施安乐死。收集血液和器官进行进一步分析。益生菌减少了系统性炎症，并对肝脏，肾脏，脾脏，脂质状况和血清葡萄糖水平具有保护作用。它几乎完全废除了生化，血液和激素参数的变化，并减轻了相对肝脏大小，食物消耗和器官组织学的变化。这些结果表明考虑将多种菌株的益生菌作为针对所研究混合物毒性的饮食治疗策略。