A series of novel thiosemicarbazones including Schiff bases were synthesized by treatment of various aryl-substituted aldehydes with thiosemicarbazides in ethanol containing one drop of hydrochloric acid at reflux for 3–5 h. For this, thiosemicarbazides were obtained from hydrazine monohydrate and isothiocyanates in cold dry ethanol at 0 °C for 1 h. FT-IR, ¹H NMR, ¹³C NMR, and LC–MS/MS spectroscopic methods and elemental analysis were used to characterize the identification of the synthesized products. The in vitro antioxidant activity of these compounds was tested by the 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical trapping method. All of the synthesized compounds showed lower antioxidant activity than the ascorbic acid standard and followed the sequence I > VII > X > VI > IV > IX > XI > II > V > III > VIII.

通过在含有一滴盐酸的乙醇中回流3到5小时，用硫代氨基脲处理各种芳基取代的醛，合成了包括席夫碱在内的一系列新型硫代氨基脲。为此，从一水合肼和异硫氰酸酯在冷的干燥乙醇中于0°C加热1 h获得硫代氨基脲。FT-IR，¹ H NMR，¹³ C NMR和LC-MS / MS光谱方法和元素分析被用来表征合成产物的鉴定。这些化合物的体外抗氧化活性通过1,1-二苯基-2-吡啶基肼基（DPPH）自由基捕获法进行了测试。所有合成的化合物均显示出比抗坏血酸标准更低的抗氧化活性，并遵循序列I >  VII  >  X  >  VI  >  IV  >  IX  >  XI  >  II  >  V  >  III  >  VIII。