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Multicomponent reaction for the synthesis of highly functionalized piperidine scaffolds catalyzed by TMSI
Research on Chemical Intermediates ( IF 3.3 ) Pub Date : 2020-07-06 , DOI: 10.1007/s11164-020-04208-6
Lisha Wu , Shiqiang Yan , Wensheng Wang , Yinta Li

An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature, giving desired substituted pyridines in moderate to good yields.



中文翻译:

TMSI催化的多组分反应合成高度官能化的哌啶骨架

报道了一种通过β-酮酸酯,芳族醛和芳族胺的一锅多米诺反应合成高官能化哌啶的有效方法。室温下在甲醇中,TMSI催化这种多组分偶联,得到所需的取代吡啶。

更新日期:2020-07-06
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