The lipid bilayer is the basis of the structure and function of the cell membrane. The study of the molecular phenomena that affect biological membranes has a great impact on the understanding of cellular physiology. To understand these phenomena, it has become increasingly necessary to develop simple synthetic models that allow the most basic details of such processes to be reproduced. In this short communication, we took advantage of the properties of two well-established lipid model systems, GUVs and SLBs, with compositions mimicking the cell membrane present in mammals and bacteria, to study the thermotropic phase behavior of lipids as well as the effect of daptomycin, a cyclic lipopeptide used as an antibiotic. The study of mechanical and thermodynamical properties of these model systems could contribute to establish a theoretical framework to develop more efficient strategies for biological control.

脂质双层是细胞膜结构和功能的基础。影响生物膜的分子现象的研究对细胞生理学的理解有很大的影响。为了理解这些现象，开发简单的合成模型变得越来越必要，该模型可以重现此类过程的最基本细节。在这段简短的交流中，我们利用了两个公认的脂质模型系统GUV和SLB的特性，它们模仿了哺乳动物和细菌中存在的细胞膜，从而研究了脂质的热致变相行为以及对脂质的影响。达托霉素，一种用作抗生素的环状脂肽。