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Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse-Mechanisms of Functioning and Control Methods.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-07-06 , DOI: 10.1134/s1607672920030126
S D Varfolomeev 1 , V I Bykov 2 , S B Tsybenova 2
Affiliation  

Abstract

In the framework of the kinetic model, the functioning of the cholinergic synapse is considered. The results of mathematical modeling of changes in the level of acetylcholine, induced pH impulse, the influence of the frequency of impulse transmission and inhibition of acetylcholinesterase are presented. Physicochemical explanation for a number of important physiological phenomena, such as neuromuscular paralysis, the molecular mechanism of neurological memory, and actions of nerve poisons and toxins, is given.


中文翻译:

人脑中化学过程的动力学。功能和控制方法的胆碱能突触机制。

摘要

在动力学模型的框架中,考虑了胆碱能突触的功能。给出了对乙酰胆碱水平变化,诱导的pH冲激,冲激传递频率的影响和乙酰胆碱酯酶抑制作用进行数学建模的结果。给出了许多重要生理现象的物理化学解释,例如神经肌肉麻痹,神经记忆的分子机制以及神经毒物和毒素的作用。
更新日期:2020-07-06
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