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Perineural spread to the brachial plexus: a focused review of proposed mechanisms and described pathologies.
Acta Neurochirurgica ( IF 2.4 ) Pub Date : 2020-07-06 , DOI: 10.1007/s00701-020-04466-8
Nikhil K Murthy 1 , Kimberly K Amrami 2 , Robert J Spinner 1
Affiliation  

Background

Perineural spread (PNS) is an emerging mechanism for progressive, non-traumatic brachial plexopathy. We aim to summarize the pathologies (tumor and infection) shown to have spread along or to the brachial plexus, and identify the proposed mechanisms of perineural spread.

Methods

A focused review of the literature was performed pertaining to pathologies with identified perineural spread to the brachial plexus.

Results

We summarized pathologies currently reported to have PNS in the brachial plexus and offer a structure for understanding and describing these pathologies with respect to their interaction with the peripheral nervous system.

Conclusions

Perineural spread is an underrepresented entity in the literature, especially regarding the brachial plexus. It can occur via a primary or secondary mechanism based on the anatomy, and understanding this mechanism helps to support biopsies of sacrificial nerve contributions, leading to more effective and timely treatment plans for patients.



中文翻译:

周围神经扩散至臂丛神经:对提出的机制和所描述的病理学进行了重点回顾。

背景

神经周围扩散(PNS)是进行性,非创伤性臂丛神经病变的新兴机制。我们的目的是总结已显示出沿臂丛神经扩散或向臂丛神经扩散的病理(肿瘤和感染),并确定拟议的神经周围扩散机制。

方法

对与病理相关的文献进行了集中的回顾,这些病理与神经周扩散到臂丛神经有关。

结果

我们总结了目前报道的臂丛神经中有PNS的病理,并提供了一种结构来理解和描述这些病理及其与周围神经系统的相互作用。

结论

在文献中,尤其是关于臂丛神经,神经周围扩散是代表性不足的实体。它可以通过基于解剖结构的主要或次要机制发生,并且了解该机制有助于支持牺牲性神经贡献的活检,从而为患者提供更有效,更及时的治疗计划。

更新日期:2020-07-06
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