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Safety and efficacy concerns of modern strategies of local anesthetics delivery.
3 Biotech ( IF 2.8 ) Pub Date : 2020-07-06 , DOI: 10.1007/s13205-020-02309-y
Mingxin Ji 1 , Guoliang Liu 1 , Yunfeng Cui 1 , Peng Zhao 1
Affiliation  

In the last few decades, several formulations have evolved to realize better efficacy of administered anesthesia. These innovative formulations have facilitated surgeons to perform operations under purely local anesthesia, which provides extra protection and comfort to patients. Ease of delivery of local anesthesia is the need of the current generation, because some of the standard procedures are performed without the use of any sedative agent. Therefore, we are presenting here the various approaches of administration of local anesthetics by the surgeons. To construct a comprehensive report on various methods of anesthesia, we followed a systematic literature search of bibliographic databases of published articles recently in the international journals and publishers of repute. A comprehensive study of several reports of the field indicates that there are significant progresses towards developing novel formulations of anesthesia drugs as well as strategies of delivery. Among formulations, nanoparticle-based delivery approaches, including polymeric, liposomal, and micellar structures, have offered the much needed efficacy with low toxicity. Therefore, several of such techniques are at various stages of clinical trials. Nanotechnology-based delivery approaches have significantly emerged in recent past due to the low systemic toxicity and better efficacy of the nonconventional local anesthetics. The other methods of local anesthesia delivery such as transdermal, magnetophoresis, electrophoresis, and iontophoresis are frequently used due to them being minimally invasive and locally effective. Therefore, the combination of the nanotechnological methods with above mentioned techniques would significantly enhance the overall process of local anesthesia delivery and efficacy.



中文翻译:

现代局麻药递送策略的安全性和有效性问题。

在过去的几十年里,几种配方已经发展到实现更好的麻醉效果。这些创新配方有助于外科医生在纯局部麻醉下进行手术,为患者提供额外的保护和舒适度。局部麻醉的易用性是当代人的需要,因为一些标准程序是在不使用任何镇静剂的情况下进行的。因此,我们在此介绍外科医生使用局部麻醉剂的各种方法。为了构建关于各种麻醉方法的综合报告,我们对最近在国际期刊和知名出版商上发表的文章的书目数据库进行了系统的文献检索。对该领域多份报告的综合研究表明,在开发新型麻醉药物配方和给药策略方面取得了重大进展。在制剂中,基于纳米颗粒的递送方法,包括聚合物、脂质体和胶束结构,提供了急需的低毒性功效。因此,一些此类技术正处于临床试验的不同阶段。由于非传统局麻药的全身毒性低和疗效更好,基于纳米技术的给药方法在最近显着出现。其他局部麻醉给药方法如透皮、磁泳、电泳和离子电渗疗法由于其微创和局部有效而经常使用。所以,

更新日期:2020-07-06
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