Abstract

Vitamin D receptor (VDR) gene polymorphisms are believed to be involved in the obesity pathogenesis. This study summarises the results of research concerning the association between VDR polymorphisms and obesity. For this survey, the records of common databases were searched until November 2019. Four loci of the VDR gene in four case-controlled and 22 cross-sectional studies were assessed and evaluated. In the case-control studies, no significant association was observed between ApaI and FokI polymorphism with obesity risk. TaqI “T” allele in two studies was related to a higher risk of obesity. One investigation found no relationship between BsmI and obesity, while another article suggested that the “b” allele is more frequently found in obese subjects. The results of cross-sectional studies did not lead to consistent findings. Although the previous studies failed to arrive at conclusive findings, the effects of VDR polymorphism on obesity development cannot be ignored.

摘要

维生素 D 受体 (VDR) 基因多态性被认为与肥胖发病机制有关。本研究总结了有关 VDR 多态性与肥胖之间关联的研究结果。在本次调查中，检索了截至 2019 年 11 月的公共数据库记录。对四项病例对照研究和 22 项横断面研究中的四个 VDR 基因位点进行了评估和评估。在病例对照研究中，未观察到 ApaI 和 FokI 多态性与肥胖风险之间存在显着关联。两项研究中的 TaqI“T”等位基因与较高的肥胖风险有关。一项调查发现 BsmI 与肥胖之间没有关系，而另一篇文章表明“b”等位基因在肥胖受试者中更常见。横断面研究的结果并没有得出一致的结论。