当前位置: X-MOL 学术FEBS Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Complement in Sepsis ‐ when Science meets Clinics
FEBS Letters ( IF 3.5 ) Pub Date : 2020-07-21 , DOI: 10.1002/1873-3468.13881
Tom E Mollnes 1, 2, 3, 4 , Markus Huber-Lang 5
Affiliation  

Sepsis as life-threatening organ dysfunction caused by microorganisms represents a dreadful challenge for the immune system. The role of the complement system as major column of innate immunity has been extensively studied in various sepsis models but its translational value remains in the dark. Complement activation products, such as C3a and C5a, and their corresponding receptors provide useful diagnostic tools and promising targets to improve organ function and outcome. However, a mono-therapeutic complement intervention irrespective of the current immune function seems insufficient to reverse the complex sepsis mechanisms. Indeed, sepsis-induced disturbances of cross-talking complement, coagulation, and fibrinolytic cascades lead to systemic "thromboinflammation", ultimately followed by multiple organ failure. We propose to reliably monitor the complement function in the patient and to re-establish the immune balance by patient-tailored combined therapies, such as complement and Toll-like receptor inhibition. Our working hypothesis aims at blocking the "explosive" innate immune recognition systems early on before downstream mediators are released and the inflammatory response becomes irreversible, a strategy that we name "upstream approach".

中文翻译:

脓毒症的补充——当科学遇到诊所

脓毒症是由微生物引起的危及生命的器官功能障碍,对免疫系统来说是一个可怕的挑战。补体系统作为先天免疫的主要柱子的作用已在各种败血症模型中得到广泛研究,但其转化价值仍处于未知状态。补体激活产物,如 C3a 和 C5a,及其相应的受体提供了有用的诊断工具和有希望的目标,以改善器官功能和结果。然而,不管当前免疫功能如何,单一治疗补体干预似乎不足以逆转复杂的败血症机制。事实上,败血症引起的串扰补体、凝血和纤维蛋白溶解级联反应会导致全身性“血栓炎症”,最终导致多器官衰竭。我们建议可靠地监测患者的补体功能,并通过为患者量身定制的联合疗法(例如补体和 Toll 样受体抑制)重新建立免疫平衡。我们的工作假设旨在在下游介质释放和炎症反应变得不可逆转之前及早阻断“爆炸性”先天免疫识别系统,我们将这种策略称为“上游方法”。
更新日期:2020-07-21
down
wechat
bug