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Modeling and imaging of intestinal electrical impedance based on conjugate gradient method.
International Journal for Numerical Methods in Biomedical Engineering ( IF 2.1 ) Pub Date : 2020-07-04 , DOI: 10.1002/cnm.3383
Peng Ran 1, 2 , Zhichao Liu 1, 2 , Chen Zeng 2 , Zhangyong Li 1 , Jiewen Deng 1 , Jingwen Wang 1
Affiliation  

Colorectal disease is a digestive tract disease of high incidence worldwide. Its preliminary diagnosis methods such as anal digital diagnosis and enteroscopy are somewhat subjective. Moreover, it is difficult to locate precisely the lesions and their infiltration boundaries for an accurate diagnosis of disease. This study combines endoscope with electrodes placed on the inner wall of the intestine to obtain both the traditional image of the intestine lumen and its electrical impedance tomography (EIT). The spatial impedance distribution image is reconstructed from the data collected by different combination of excitation and detection electrodes. The multidimensional and multiparameter intestinal physiological and pathological changes can thus be analyzed by EIT. This study mainly consists of the following three contributions: (a) construct certain physical models that reflect corresponding characteristics of intestinal tissue and its pathological changes; (b) optimize targeted signal acquisition methods suitable for data processing and analysis of intestinal cavity; and (c) establish a method of image reconstruction that conforms to the morphological characteristics of the intestinal cavity, so that comparative analysis can be applied by using different algorithms for image reconstruction. Through the extraction and analysis of impedance information for intestinal characteristics, we aim to make this tool a supplementary diagnosis method of high sensitivity and specificity for related diseases. This may lay a foundation for more accurate clinical screening of high‐risk population, more precise diagnosis and localization of lesion characteristics, and thus better treatment guidance.

中文翻译:

基于共轭梯度法的肠道电阻抗建模与成像[J].

结直肠疾病是世界范围内发病率高的消化道疾病。其初步诊断方法如肛门指诊、小肠镜检查等具有一定的主观性。此外,难以精确定位病变及其浸润边界以准确诊断疾病。本研究将内窥镜与放置在肠内壁上的电极相结合,以获得肠腔的传统图像及其电阻抗断层扫描 (EIT)。空间阻抗分布图像是由不同激发电极和检测电极组合采集的数据重建而成的。从而可以通过 EIT 分析多维度和多参数的肠道生理和病理变化。本研究主要包括以下三个贡献:(a) 构建某些反映肠道组织相应特征及其病理变化的物理模型;(b) 优化适合肠腔数据处理和分析的靶向信号采集方法;(c) 建立符合肠腔形态特征的图像重建方法,以便使用不同的图像重建算法进行对比分析。通过对肠道特征阻抗信息的提取和分析,我们旨在使该工具成为对相关疾病具有高灵敏度和特异性的辅助诊断方法。这可能为更准确的高危人群临床筛查、更精确的诊断和病灶特征定位奠定基础,
更新日期:2020-07-04
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