Exposure to high concentrations of particulate matter (PM) is associated with a number of adverse health effects. However, it is unclear which aspects of PM are most hazardous, and a better understanding of particle sizes and personal exposure is needed. We characterized particle size distribution (PSD) from biomass‐related pollution and assessed total and regional lung‐deposited doses using multiple‐path deposition modeling. Gravimetric measurements of kitchen and personal PM_2.5 (<2.5 µm in size) exposures were collected in 180 households in rural Puno, Peru. Direct‐reading measurements of number concentrations were collected in a subset of 20 kitchens for particles 0.3‐25 µm, and the continuous PSD was derived using a nonlinear least‐squares method. Mean daily PM_2.5 kitchen concentration and personal exposure was 1205 ± 942 µg/m³ and 115 ± 167 µg/m³, respectively, and the mean mass concentration consisted of a primary accumulation mode at 0.21 µm and a secondary coarse mode at 3.17 µm. Mean daily lung‐deposited surface area (LDSA) and LDSA during cooking were 1009.6 ± 1469.8 µm²/cm³ and 10,552.5 ± 8261.6 µm²/cm³, respectively. This study presents unique data regarding lung deposition of biomass smoke that could serve as a reference for future studies and provides a novel, more biologically relevant metric for exposure‐response analysis compared to traditional size‐based metrics.

中文翻译：

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来自家庭接触生物质烟雾的颗粒物的尺寸分布和肺沉积剂量。

接触高浓度的颗粒物 (PM) 会导致许多不利的健康影响。然而，目前尚不清楚 PM 的哪些方面最危险，需要更好地了解颗粒大小和个人暴露。我们表征了来自生物质相关污染的粒度分布 (PSD)，并使用多路径沉积模型评估了总和区域肺沉积剂量。在秘鲁普诺农村的 180 户家庭中收集了厨房和个人 PM _2.5（尺寸<2.5 µm）暴露的重量测量值。在 20 个厨房的子集中收集了 0.3-25 µm 颗粒的数量浓度的直读测量值，并使用非线性最小二乘法推导出连续 PSD。平均每日 PM _2.5厨房浓度和个人接触浓度分别为 1205 ± 942 µg/m ³和 115 ± 167 µg/m ³，平均质量浓度由 0.21 µm 处的初级积累模式和 3.17 µm 处的二级粗模式组成。平均每日肺沉积表面积 (LDSA) 和烹饪过程中的 LDSA 分别为 1009.6 ± 1469.8 µm ² /cm ³和 10,552.5 ± 8261.6 µm ² /cm ³。本研究提供了关于生物质烟雾肺沉积的独特数据，可作为未来研究的参考，并为暴露-反应分析提供了一种新的、更具有生物学相关性的指标，与传统的基于尺寸的指标相比。