A selective chitosan-based ion exchange molecular imprinted polymer (MIP) was prepared for ketorolac (KET) using the sol-gel method and glutaraldehyde as a crosslinker. The nonimprinted polymer (NIP) was prepared and used as a control, during the whole experiment. The chemical and morphological characteristics of the prepared polymers were investigated using FTIR and SEM, respectively. The prepared MIP was applied to determine the optimum operational conditions for KET extraction from dilute aqueous solutions. The adsorption step was performed at pH 5 and a contact time of 20 min, using 0.1 N HCl as an elution solvent for 30 min. The specificity of the prepared polymer was indicated by an imprinting factor of 1.45. The prepared MIP was successfully applied for selective solid phase extraction and subsequent determination of KET in spiked human plasma samples over a range of 2–20 μg/mL, with a mean % recovery of 94.62% using derivative spectroscopy.

使用溶胶-凝胶法和戊二醛作为交联剂，制备了用于酮咯酸（KET）的选择性壳聚糖基离子交换分子印迹聚合物（MIP）。在整个实验过程中，准备了非印迹聚合物（NIP），并将其用作对照。分别使用FTIR和SEM研究了所制备聚合物的化学和形态特征。所制备的MIP用于确定从稀水溶液中萃取KET的最佳操作条件。吸附步骤在pH 5和20分钟的接触时间下进行，使用0.1 N HCl作为洗脱溶剂30分钟。制备的聚合物的特异性由1.45的压印因子指示。