The prevalence of degenerative diseases increases with age. Furthermore, various factors tend to trigger cells injury, thereby, causing inflammation. This study, therefore, aims to examine the anti-inflammatory mechanisms of steeping date seeds in middle age women. This is a quasi-experimental design with a pre- and post-test approach used to evaluate the anti-inflammatory effect of 2.5 g of steeped of date palm seed, consumed by 30 healthy middle-aged women per day (in 250 mL water) for 14 days. The final numbers (22 subjects) of recruited women were included in the statistical analysis. Their level of IL-1β, TGF-β, IL-6, TNF-α, IL-12, COX-1, COX-2, and PGE2 were determined using ELISA. The results showed that the expression of IL-1β, TGF-β, COX-1, and COX-2 in women significantly decreased after consuming date palm seed. Steeped of date seed acts as an anti-inflammatory by downregulating the expression of key proinflammatory mediators.

退化性疾病的患病率随年龄增长而增加。此外，各种因素倾向于触发细胞损伤，从而引起炎症。因此，本研究旨在检查中年妇女浸泡枣种子的抗炎机制。这是一种准实验设计，采用前后测试的方法来评估2.5克浸泡的枣椰子种子的抗炎作用，每天有30位健康的中年女性在250毫升水中食用持续14天。统计分析中包括了最终招募的女性人数（22名受试者）。使用ELISA测定它们的IL-1β，TGF-β，IL-6，TNF-α，IL-12，COX-1，COX-2和PGE2的水平。结果表明，食用椰枣种子的女性中IL-1β，TGF-β，COX-1和COX-2的表达明显降低。