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Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review.
Molecular and Cellular Probes ( IF 3.3 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.mcp.2020.101636
Raheleh Torabi 1 , Reza Ranjbar 2 , Mehrdad Halaji 3 , Mohammad Heiat 4
Affiliation  

The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.



中文翻译:

适体,作为冠状病毒感染探针和疗法的二价试剂:系统评价。

最近已知的冠状病毒 SARS-CoV-2 已成为全球最大的健康挑战,影响着许多社会。缺乏特异性治疗和金标准诊断系统使情况更加复杂。努力导致生产了几种诊断试剂盒,这些试剂盒存在灵敏度和准确性不足等局限性。作为多能生物探针的适体可能是设计灵敏和特异性生物传感器的有前途的候选者。虽然很少有研究介绍冠状病毒的特定适配体类型,但它们可能有助于我们选择最佳途径来获得针对该病毒的特定适配体。另一方面,一些已经引入的适体已经显示出对冠状病毒的抑制作用,可以用作治疗剂。

更新日期:2020-07-08
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