当前位置: X-MOL 学术Biomater. Adv. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Multi-transformable nanocarrier with tumor extracellular acidity-activated charge reversal, size reduction and ligand reemergence for in vitro efficient doxorubicin loading and delivery.
Biomaterials Advances ( IF 7.9 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.msec.2020.111250
Jumin Yang 1 , Shuai Liu 1 , Zhanpeng Ye 1 , Liandong Deng 1 , Anjie Dong 2 , Jianhua Zhang 3
Affiliation  

Various nanoparticles as drug delivery system provide significant improvements in the cancer treatment. However, their clinical success remains elusive in large part due to their inability to overcome both systemic and tumor tissue barriers. The nanosystems with nanoproperty-transformability (surface, size, stability and target) hold great promise for achieving enhanced delivery efficacy. However, currently available systems that are mainly polymer-based assemblies usually suffer from the intrinsic drawbacks of poor stability, premature leakage and low drug loading as well as limited transformability. In this study, we designed a facile strategy to build a novel multi-transformable MSNs@GO nanosystem for efficient doxorubicin (DOX) loading and delivery. This novel nanosystem was well characterized and investigated in vitro. The results indicated that the MSNs@GO can realize a very high drug loading ability due to the large pore surface area of MSNs and the demonstrated donor-acceptor (boron‑nitrogen) coordination interactions between phenylboronic acid-containing nanocarriers and electron donor-containing DOX. More importantly, the novel nanocarriers can simultaneously achieve charge reversal, size reduction and ligand reemergence by shielding/deshielding transition via acid-cleavable dynamic boronate bonds under in vitro simulated acidic microenvironment of tumor tissues, opening a new avenue for improving delivery efficiency of chemotherapeutics.



中文翻译:

具有肿瘤细胞外酸度激活的电荷逆转,尺寸减小和配体重新出现的多转化纳米载体,用于体外有效的阿霉素加载和递送。

各种作为药物递送系统的纳米颗粒在癌症治疗中提供了显着的改善。然而,由于其无法克服全身性和肿瘤性组织障碍,其临床成功在很大程度上仍然难以捉摸。具有纳米性能可转换性(表面,尺寸,稳定性和靶标)的纳米系统有望实现更高的传递功效。然而,当前主要是基于聚合物的组件的可用系统通常遭受固有的缺点,即稳定性差,渗漏过早,药物载量低以及可转换性有限。在这项研究中,我们设计了一种简便的策略来构建新型的多转化MSNs @ GO纳米系统,以高效地装载和输送阿霉素(DOX)。这种新颖的纳米系统已得到很好的表征,并在体外进行了研究。结果表明,MSNs @ GO可以实现很高的载药能力,这是由于MSNs的大孔表面积以及已证明的含苯基硼酸的纳米载体与含电子供体的DOX之间的供体-受体(硼-氮)配位相互作用。更重要的是,新型的纳米载体可以在体外模拟的肿瘤组织酸性微环境下通过酸可裂解的动态硼酸酯键进行屏蔽/去屏蔽转变,从而同时实现电荷反转,尺寸减小和配体重新出现,从而为提高化学治疗剂的输送效率开辟了一条新途径。

更新日期:2020-07-04
down
wechat
bug