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Correlations between COVID-19 and burden of dementia: An ecological study and review of literature
Journal of the Neurological Sciences ( IF 4.4 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jns.2020.117013
M Reza Azarpazhooh 1 , Amin Amiri 2 , Negar Morovatdar 3 , Sandy Steinwender 4 , Amir Rezaei Ardani 5 , Nawaf Yassi 6 , Jose Biller 7 , Saverio Stranges 8 , Masoud Tokazebani Belasi 9 , Sepideh Kazemi Neya 9 , Bita Khorram 10 , Mohammad Sobhan Sheikh Andalibi 11 , Shahram Arsang-Jang 12 , Naghmeh Mokhber 13 , Mario Di Napoli 14
Affiliation  

Abstract Introduction Current evidence on the association between COVID-19 and dementia is sparse. This study aims to investigate the associations between COVID-19 caseload and the burden of dementia. Methods We gathered data regarding burden of dementia (disability-adjusted life years [DALYs] per 100,000), life expectancy, and healthy life expectancy (HALE) from the Global Burden of Disease (GBD) 2017 study. We obtained COVID-19 data from Our World in Data database. We analyzed the association of COVID-19 cases and deaths with the burden and mortality of dementia using Spearman's rank correlation coefficient. Results Globally, we found significant positive (p < .001) correlations between life expectancy (r = 0.60), HALE (r = 0.58), and dementia DALYs (r = 0.46) with COVID-19 caseloads. Likewise, we found similar correlations between life expectancy (r = 0.60), HALE (r = 0.58) and dementia DALYs (r = 0.54) with COVID-19 mortality. Conclusion Health policymakers should clarify a targeted model of disease surveillance in order to reduce the dual burden of dementia and COVID-19.

中文翻译:

COVID-19 与痴呆症负担之间的相关性:生态研究和文献综述

摘要 简介 目前关于 COVID-19 与痴呆症之间关联的证据很少。本研究旨在调查 COVID-19 病例数与痴呆症负担之间的关联。方法 我们从 2017 年全球疾病负担 (GBD) 研究中收集了有关痴呆症负担(每 100,000 人的残疾调整生命年 [DALY])、预期寿命和健康预期寿命 (HALE) 的数据。我们从 Our World in Data 数据库中获取了 COVID-19 数据。我们使用 Spearman 等级相关系数分析了 COVID-19 病例和死亡与痴呆症负担和死亡率的关联。结果 在全球范围内,我们发现预期寿命 (r = 0.60)、HALE (r = 0.58) 和痴呆 DALY (r = 0.46) 与 COVID-19 病例数之间存在显着正相关 (p < .001)。同样,我们发现预期寿命 (r = 0.60)、HALE (r = 0.58) 和痴呆 DALY (r = 0.54) 与 COVID-19 死亡率之间存在类似的相关性。结论 卫生政策制定者应明确有针对性的疾病监测模式,以减轻痴呆症和 COVID-19 的双重负担。
更新日期:2020-09-01
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