A set of new 1-(2-ethoxy-2-oxoethyl)imidazolium-based ionic liquids (1–16) have been prepared via the alkylation reaction of ethyl 2-(1H-imidazol-1-yl)acetate with various type of substituted alkyl halides using a microwave irradiation reaction in yields above 90%. The chemical structures of the manufactured ILs (1–16) were analyzed by mass and NMR spectroscopy. The newly prepared ILs were examined for their in vitro anti-microbial activities towards different types of Gram (+) and Gram (−) bacteria, and also for their antifungal activities. The preliminary tests showed that most of the resultant ILs presented modest activities towards S. aureus and B. subtilis with IZ values ranging between 10 and 14 mm, while the E. coli activities was in the range of 16 and 20 mm. However, ILs (1–16) displayed poor activities against the C. albicans.

一组新的1-（2-乙氧基-2-氧代乙基）咪唑鎓的离子液体（1 - 16）已准备经由乙基2-（1H-咪唑-1-基）乙酸甲酯与各种类型的烷基化反应用微波辐射反应取代的烷基卤化物的收率超过90％。所制造的离子液体（的化学结构1 - 16）通过质谱和NMR光谱进行分析。检查新制备的IL对不同类型的革兰氏（+）和革兰氏（-）细菌的体外抗菌活性，以及​​它们的抗真菌活性。初步测试表明，大多数合成的IL对金黄色葡萄球菌和枯草芽孢杆菌均表现出适度的活性。IZ值在10到14毫米之间，而大肠杆菌的活性在16到20毫米之间。但是，白介素（1 – 16）对白念珠菌的活性较弱。