当前位置: X-MOL 学术Hum. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Regulatory noncoding RNAs and the major histocompatibility complex
Human Immunology ( IF 2.7 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.humimm.2020.06.005
Nilesh Sunil Chitnis 1 , Mengkai Shieh 1 , Dimitri Monos 2
Affiliation  

The Major Histocompatibility Complex (MHC) is a 4 Mbp genomic region located on the short arm of chromosome 6. The MHC region contains many key immune-related genes such as Human Leukocyte Antigens (HLAs). There has been a growing realization that, apart from MHC encoded proteins, RNAs derived from noncoding regions of the MHC—specifically microRNAs (miRNAs) and long noncoding RNAs (lncRNAs)—play a significant role in cellular regulation. Furthermore, regulatory noncoding RNAs (ncRNAs) derived from other parts of the genome fine-tune the expression of many immune-related MHC proteins. Although the field of ncRNAs of the MHC is a research area that is still in its infancy, ncRNA regulation of MHC genes has already been shown to be vital for immune function, healthy pregnancy and cellular homeostasis. Dysregulation of this intricate network of ncRNAs can lead to serious perturbations in homeostasis and subsequent disease.



中文翻译:

调节性非编码 RNA 和主要组织相容性复合体

主要组织相容性复合体 (MHC) 是位于 6 号染色体短臂的 4 Mbp 基因组区域。 MHC 区域包含许多关键的免疫相关基因,如人类白细胞抗原 (HLA)。人们越来越认识到,除了 MHC 编码的蛋白质外,源自 MHC 非编码区的 RNA——特别是微 RNA (miRNA) 和长链非编码 RNA (lncRNA)——在细胞调控中发挥着重要作用。此外,来自基因组其他部分的调节性非编码 RNA (ncRNA) 可以微调许多免疫相关 MHC 蛋白的表达。尽管 MHC 的 ncRNA 领域仍处于起步阶段,但 MHC 基因的 ncRNA 调控已被证明对免疫功能、健康怀孕和细胞稳态至关重要。

更新日期:2020-07-04
down
wechat
bug